TSG101 anticorps

N° du produit ABIN190317

Cet anticorps anti-TSG101 est un anticorps Souris Monoclonal détectant TSG101 dans WB, IP, IF/ICC, PLA et BP. Adapté pour Humain.

Aperçu rapide pour TSG101 anticorps (ABIN190317)

Antigène: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TSG101 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC), Proximity Ligation Assay (PLA), Blocking Peptide (BP)

Clone: 1F3

Détail du produit anti-TSG101 anticorps

Fonction: Anti-DNA Ligase III Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and chicken DNA Ligase III. Cellular localization is nuclear and mitochondrial.

Réactivité croisée: Poulet, Humain, Souris

Immunogène: Full-length recombinant human DNA Ligase III-b.

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 0.5-2 μg/mL. Predicted molecular weight ~100 kDa.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: Hybridoma culture supernatant

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

Détails sur TSG101

Antigène: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Autre désignation: TSG101

Sujet: DNA ligase 3,Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {PubMed:10207110, PubMed:24674627}.,There are four distinct ligase proteins found in mammalian cells. These DNA ligases are required for joining DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III is a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed, and complexes with XRCC-1 and a 97 kDa ( -form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in base excision repair pathway.,[Isoform 1]: Mitochondrion,EC 6.5.1.1, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3

UniProt: P49916